Would love to see someone like Jim Butcher do an Inquisition type novel. I love his writing, especially The Dresden Files, though he'd obviously need to tone down his usual bits of humour to work with a 40k story. But alas, it will never happen.
The human appendix. Proof of a higher power. A divine kill switch so to speak.
No one really likes a smartass, but people tend to like a dumbass even less.