I don't think they would be successful at all. They will do a huge amount of damage but will most likely take crippling damage themselves.
I think the main things here it wouldn't be just the dark eldar. If it was a full blown extermination I sincerely believe the Craftworlds would get involved and not just them but the Harlequins as well. Now they are facing 3 "worlds" military.
That and as previously stated the "nodes" can be cut off from each other and nothing spoils a legions day than being isolated in an area when a black hole is opened up.
Don't, after rolling that final 1 too many, flip out, climb up on the table and jump up and down on your opponent's models screaming 'APOCALYPTIC BARRAGE, MOTHERFUCKER!!!'.